Research
The research in Dr. Eghbali’s lab is focused on understanding the molecular and cellular mechanisms underlying the development and progression of heart disease (heart failure, myocardial ischemia/reperfusion injury, and cardiac arrest induced by anesthetic overdose), and lung disease (pulmonary hypertension and acute lung injury), and to develop novel therapeutics such as micro-RNAs for heart disease and lung disease. Her lab also studies sex differences in cardiovascular disease in particular the role of estrogen, estrogen receptors and more recently the role of sex chromosomes.
Here are some of the ongoing research projects:
- Molecular Mechanisms underlying transition of pulmonary fibrosis to pulmonary hypertension
- Role of oxidized lipids and intestinal inflammation in pulmonary arterial hypertension
- Role of sex Chromosomes in Pulmonary Hypertension
- Role of Intralipid in protecting the heart against ischemia/reperfusion injury
- Molecular mechanisms underlying higher susceptibility of the heart to ischemia/reperfusion injury in late pregnancy
- Molecular mechanisms underlying Rescue of Bupivacaine Induced Cardiotoxicity by Intralipid
- Protective Role of miR129 against myocardial fibrosis and calcification